PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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(S,E)-TCO2-PEG3-acid
0 ImagesCat. No.: HY-140015A
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Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride
![Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w057330.gif "Click to View Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W057330CAS No.: 1638765-19-1
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2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)acetic acid
0 ImagesCat. No.: HY-W986741CAS No.: 909282-26-4
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Methyl 10-hydroxydecanoate
0 ImagesCat. No.: HY-W404252CAS No.: 2640-94-0
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Benzyl 5-hydroxypentanoate
0 ImagesCat. No.: HY-W130690CAS No.: 134848-96-7
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Hex-3-enedinitrile
0 ImagesCat. No.: HY-W130918ACAS No.: 1119-85-3
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4-(Azetidin-3-yl)piperazin-2-one hydrochloride
0 ImagesCat. No.: HY-W612110CAS No.: 1624260-62-3
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4-Bromobutyl acetate
0 ImagesCat. No.: HY-W130241CAS No.: 4753-59-7
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5-Aminopentanoic acid hydrochloride
0 ImagesCat. No.: HY-W111909CAS No.: 627-95-2
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endo-BCN-PEG3-NHS ester
0 ImagesCat. No.: HY-140068CAS No.: 2141976-24-9
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22-Bromodocosanoic acid
0 ImagesCat. No.: HY-W460259CAS No.: 78774-39-7
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4-Azidobutylamine (Standard)
0 ImagesCat. No.: HY-108374RCAS No.: 88192-20-54-Azidobutylamine (Standard) is the analytical standard of 4-Azidobutylamine (HY-108374). This product is intended for research and analytical applications. 4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate
![tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w613883.gif "Click to View tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W613883CAS No.: 122632-07-9
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tert-Butyl (3-aminopropyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W000835CAS No.: 127346-48-9
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Cbz-NH-C4-O-NH2
0 ImagesCat. No.: HY-W415279CAS No.: 1359993-60-4
